For enhanced safety, the front and second-row seat shoulder belts of the Toyota Highlander Hybrid have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Jeep Grand Cherokee L doesn’t offer pretensioners for its second-row seat belts.
With its standard Pre-Collision System with Pedestrian Detection, the Toyota Highlander Hybrid is better at preventing collisions with pedestrians than the Jeep Grand Cherokee L, according to the Insurance Institute for Highway Safety:
| 
 | Highlander Hybrid | Grand Cherokee L | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| 
 | Crossing Child - DAY | |
| 12 MPH | AVOIDED | AVOIDED | 
| 25 MPH | -22 MPH | -11 MPH | 
| 
 | Crossing Adult - NIGHT | |
| 12 MPH Brights | AVOIDED | AVOIDED | 
| 12 MPH Low beams | AVOIDED | AVOIDED | 
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | AVOIDED | 
| 
 | Parallel Adult - NIGHT | |
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | AVOIDED | 
| Warning Issued-Low beams | 2 sec | 1.6 sec | 
The Highlander Hybrid has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Grand Cherokee L doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Both the Highlander Hybrid and Grand Cherokee L have rear cross-traffic warning, but the Highlander Hybrid Limited/Platinum has Parking Support Brake (automatically applies the brakes) to better prevent a collision when backing near traffic. The Grand Cherokee L’s Rear Cross Path Detection doesn’t automatically brake.
Both the Highlander Hybrid and the Grand Cherokee L have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, available all wheel drive and around view monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Toyota Highlander Hybrid is safer than the Grand Cherokee L:
| 
 | Highlander Hybrid | Grand Cherokee L | 
| Overall Evaluation | GOOD | GOOD | 
| Structure | GOOD | GOOD | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 71 | 163 | 
| Neck Tension | 156 lbs. | 312 lbs. | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | .51 in | 1.06 in | 
| Torso Max Deflection | 1.26 in | 1.3 in | 
| Torso Deflection Rate | 6 MPH | 7 MPH | 
| Head Protection | GOOD | GOOD | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Neck Compression | 112 lbs. | 134 lbs. | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | 1.06 in | 1.38 in | 
| Torso Max Deflection | 1.1 in | 1.69 in | 
| Torso Deflection Rate | 6 MPH | 11 MPH | 
| Pelvis | GOOD | ACCEPTABLE | 
| Pelvis Force | 201 lbs. | 915 lbs. | 
| Head Protection | GOOD | GOOD | 

