Both the Grand Highlander and the XC90 have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available all wheel drive and around view monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Toyota Grand Highlander is safer than the XC90:
| 
 | Grand Highlander | XC90 | 
| Overall Evaluation | GOOD | GOOD | 
| Structure | GOOD | GOOD | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 38 | 123 | 
| Neck Tension | 134 lbs. | 245 lbs. | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | .35 in | .91 in | 
| Shoulder Force | 156 lbs. | 245 lbs. | 
| Torso Max Deflection | 1.1 in | 1.42 in | 
| Torso Deflection Rate | 4 MPH | 7 MPH | 
| Head Protection | GOOD | GOOD | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Neck Tension | 67 lbs. | 89 lbs. | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | .67 in | 1.38 in | 
| Shoulder Force | 245 lbs. | 290 lbs. | 
| Torso Max Deflection | 1.1 in | 1.42 in | 
| Torso Deflection Rate | 6 MPH | 8 MPH | 
| Pelvis | GOOD | ACCEPTABLE | 
| Pelvis Force | 446 lbs. | 915 lbs. | 
| Head Protection | GOOD | GOOD | 

