With its standard Pre-Collision with Pedestrian Detection, the Toyota bZ4X is better at preventing collisions with pedestrians than the Honda Prologue, according to the Insurance Institute for Highway Safety:
| 
 | bZ4X | Prologue | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| 
 | Crossing Child - DAY | |
| 12 MPH | AVOIDED | AVOIDED | 
| 25 MPH | AVOIDED | AVOIDED | 
| 
 | Crossing Adult - NIGHT | |
| 12 MPH Brights | AVOIDED | AVOIDED | 
| 12 MPH Low beams | AVOIDED | AVOIDED | 
| 
 | Parallel Adult - NIGHT | |
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | AVOIDED | 
| 37 MPH Brights | AVOIDED | -19 MPH | 
| Warning Issued-Brights | 2.3 sec | 2 sec | 
| 37 MPH Low beams | AVOIDED | -19 MPH | 
| Warning Issued-Low beams | 2.1 sec | 1.7 sec | 
The bZ4X has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Prologue doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
The bZ4X’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Prologue doesn’t offer a driver alert monitor.
Both the bZ4X and the Prologue have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front wheel drive, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rear parking sensors, rear cross-path warning and available around view monitors.

