The Rav4 Prime has all-wheel drive to maximize traction under poor conditions, especially in ice and snow. The Escape PHEV doesn’t offer all-wheel drive.
Both the Rav4 Prime and the Escape PHEV have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available around view monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Toyota Rav4 Prime is safer than the Escape PHEV:
| 
 | Rav4 Prime | Escape PHEV | 
| Overall Evaluation | ACCEPTABLE | MARGINAL | 
| Structure | GOOD | ACCEPTABLE | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 120 | 391 | 
| Head Peak Forces | no contact | 93 G’s | 
| Neck Tension | 134 lbs. | 379 lbs. | 
| Torso | GOOD | MARGINAL | 
| Shoulder Deflection | .47 in | 1.1 in | 
| Shoulder Force | 178 lbs. | 223 lbs. | 
| Torso Max Deflection | 1.34 in | 1.77 in | 
| Torso Deflection Rate | 7 MPH | 8 MPH | 
| Pelvis | ACCEPTABLE | MARGINAL | 
| Pelvis Force | 1093 lbs. | 1160 lbs. | 
| Head Protection | GOOD | MARGINAL | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | .94 in | 1.54 in | 
| Shoulder Force | 290 lbs. | 379 lbs. | 
| Torso Max Deflection | .83 in | 1.5 in | 
| Pelvis | GOOD | ACCEPTABLE | 
| Pelvis Force | 692 lbs. | 1093 lbs. | 
Instrumented handling tests conducted by the National Highway Traffic Safety Administration and analysis of its dimensions indicate that the Rav4 Prime is 4.1% less likely to roll over than the Escape PHEV.

